Transcorneal stimulation of trigeminal nerve afferents to increase cerebral blood flow in rats with cerebral vasospasm: a noninvasive method to activate the trigeminovascular reflex


Atalay B., Bolay H. B. , Dalkara T., Soylemezoglu F., Oge K., Ozcan O.

JOURNAL OF NEUROSURGERY, vol.97, no.5, pp.1179-1183, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97 Issue: 5
  • Publication Date: 2002
  • Doi Number: 10.3171/jns.2002.97.5.1179
  • Journal Name: JOURNAL OF NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1179-1183
  • Keywords: subarachnoid hemorrhage, cerebral vasospasm, cerebral ischemia, cerebral blood flow, trigeminovascular reflex, rat, GENE-RELATED PEPTIDE, EXPERIMENTAL SUBARACHNOID HEMORRHAGE, ELECTRICAL-STIMULATION, GLUCOSE-METABOLISM, SQUIRREL-MONKEY, SUBSTANCE-P, PATHWAYS, DOGS
  • Gazi University Affiliated: Yes

Abstract

Object. The goal of this study was to investigate whether stimulation of trigeminal afferents in the cornea could enhance cerebral blood flow (CBF) in rats after they have been subjected to experimental subarachnoid hemorrhage (SAH). Cerebral vasospasm following SAH may compromise CBF and increase the risks of morbidity and mortality. Currently, there is no effective treatment for SAH-induced vasospasm. Direct stimulation of the trigeminal nerve has been shown to dilate constricted cerebral arteries after SAH; however, a noninvasive method to activate this nerve would be preferable for human applications. The authors hypothesized that stimulation of free nerve endings of trigeminal sensory fibers in the face might be as effective as direct stimulation of the trigeminal nerve.