Exogenous ideal delivery system for biologically active molecules is under intensive investigation. In the present study it was aimed to test the availability of different calcium phosphate biomaterials (CPBs), hydroxyapatite (HA), beta tricalcium phosphate (TCP), and a combination of these (TCP+HA) as dental pulp capping systems on healing of dog dental pulp. Experimentally perforated dental pulps of 16 premolar and molar teeth in a beagle dog were capped with CPBs. Calcium hydroxide (CH) was used as positive control. Thirty days after the operation, teeth were extracted and examined by routine histological techniques. While in HA and TCP group the pulp tissue displayed severe inflammatory response, prompted healing of the pulp tissue in TCP+HA group was seen. Complete bridge of reparative dentin formation was obvious in TCP+HA and CH groups.