Akademik Veri Yönetim Sistemi
Sabiad , cilt.7, sa.2, ss.73-80, 2024 (Hakemli Dergi)
Objective: Obesity is one of the most common health problems in the
world. The following methods are currently used to treat obesity: medical
nutrition therapy, behavioral therapy, medical treatment, and surgical
therapy. Discussions are still ongoing regarding whether changing the
plasma levels of the hormones that regulate satiety and appetite can be
used as a new add-on therapy to pre-existing obesity treatments to
decrease food consumption. One possibility for changing the levels of the
hormones that control hunger and satiety involves the use of probiotics.
This study has been planned and conducted to examine the effects of
probiotics on appetite, inflammation, and nutritional status in overweight
individuals.
Materials and Methods: The study includes 35 overweight females aged
19-30 years old to who a questionnaire form had been applied prior to the
study. Probiotics were given to these individuals for 8 weeks. Food
consumption records and anthropometric measurements were taken and
a body composition analysis conducted three times during the study.
Inflammatory markers such as CRP, TNF-α, and IL-6 and the hormone
analyses (i.e., leptin, adiponectin, cholecystokinin, ghrelin, GLP-1, and PYY)
were evaluated at the beginning and end of the study using the ELISA
method.
Results: The women were asked about their physical activity status, and
their appetite hormones and inflammatory markers were analyzed both at
the beginning and end of the study. When taken together, the study found
the individuals’ anthropometric measurements, inflammatory markers,
and hunger hormone levels to have decreased significantly and their
satiety hormone levels to have increased significantly after the use of
probiotics (p<0.05). However, no significant changes occurred regarding
their energy, macronutrients, fiber intake, or physical activity levels
(p>0.05).
Conclusion: The study clearly shows an appropriate probiotic strain to be
able to significantly affect anthropometric measurements, inflammatory
markers, and appetite hormones in overweight individuals without any
other intervention.
Keywords: Obesity, probiotics, nutritional status, hormones, inflammatory
markers