Synthesis of Indole and Benzimidazole Substituted Novel 16-Arylidene Steroid Derivatives

Karatas S., ÇAPAN İ., SERVİ S.

LETTERS IN ORGANIC CHEMISTRY, cilt.16, sa.11, ss.884-890, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 11
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570178616666190305130217
  • Dergi Adı: LETTERS IN ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.884-890
  • Anahtar Kelimeler: Dehydroepiandrosterone, indole, benzimidazole, 16-arylidene steroids, O-alkylated 4-hydroxybenzaldehydes, Aldol condensation, BIOLOGICAL EVALUATION, ANTICANCER, DEHYDROEPIANDROSTERONE, INHIBITION
  • Gazi Üniversitesi Adresli: Evet

Özet

Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes were synthesized from the reaction of substituted benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids were synthesized from the base-catalyzed aldol condensation of O-alkylated 4-hydroxybenzaldehydes and dehydroepiandrosterone. New indolyl and benzimidazolyl substituted steroid derivatives as hybrid molecules were obtained from the reaction of 16-arylidene steroids with indole or benzimidazole.