The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis

Orhan G., Eruyar E., Mungan S. O., Ak F., KARAHALİL B.

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.146, ss.96-101, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.clineuro.2016.04.027
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-101
  • Anahtar Kelimeler: Multiple sclerosis, IL-18 gene polymorphism, PCR, IL-18 activity, INTERLEUKIN-18, CYTOKINE, RESPONSES
  • Gazi Üniversitesi Adresli: Evet

Özet

Objectives: Multiple sclerosis is an inflammatory condition of the central nervous system whose etiology is influenced by immunologic, genetic, and environmental factors. Aim of the present study was to determine if any relation exists between IL-18-137C/G and -607C/A gene promoter polymorphisms on the individual susceptibility of multiple sclerosis and also to investigate the possible effect of IL-18 activity regarding this kind of polymorphism and MS.