Anti-cyclic citrullinated peptide antibodies are not associated with familial mediterranean fever

KARATAY S., Yildirim K., ERDAL A., UZKESER H., Erdem F. H., Yanmaz V.

Journal of Back and Musculoskeletal Rehabilitation, vol.23, no.1, pp.21-23, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.3233/bmr-2010-0243
  • Journal Name: Journal of Back and Musculoskeletal Rehabilitation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.21-23
  • Keywords: Anti-cyclic citrullinated peptide antibodies, Arthritis, Familial Mediterranean fever
  • Gazi University Affiliated: Yes


Objective: This study investigated the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in familial Mediterranean fever (FMF) patients and controls. Material and Methods: Forty-nine patients with FMF were enrolled (23 had a history of arthritis during attacks and 26 had no such history). Two control groups were enrolled: 20 patients with rheumatoid arthritis (RA) and 30 healthy individuals. Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), rheumatoid factor (RF), and anti-CCP antibody levels were measured. Results: In RA patients' ESR and CRP levels, frequency of RF, and anti-CCP antibody levels were significantly higher than in both FMF patients and healthy controls (p ≤ 0.001). Moreover, anti-CCP was negative in all healthy controls as well as in all FMF patients. Conclusion: Our results show that anti-CCP antibodies are not associated with FMF. © 2010 IOS Press and the authors. All rights reserved.