The expression of VLA integrins in the human thymus

Karaoz E., Ilgaz C., Erdogan D., Dagdeviren A.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, vol.178, no.1, pp.33-40, 1996 (SCI-Expanded) identifier identifier identifier


The integrin receptors are a family of transmem brane glycoproteins comprising non-covalent heterodimers. They interact with a wide variety of ligands including extracellular matrix glycoproteins, complement and other cells while their intracellular domains interact with the cytoskeleton. They participate in cell-matrix and cell-cell adhesion in many physiologically important processes including embryological development, hemostasis, thrombosis, wound healing, immune and nonimmune defense mechanisms, and oncogenic transformation. This investigation is focused on the histological distribution of the beta 1-integrins in the human thymus, using an indirect immunoperoxidase method.