Akademik Veri Yönetim Sistemi
Mediterranean Journal of Hematology and Infectious Diseases, cilt.18, sa.1, 2026 (SCI-Expanded, Scopus)
Background: Stenotrophomonas maltophilia (S. maltophilia) is a multidrug-resistant pathogen frequently isolated in hospital-acquired pneumonia and represents a significant clinical challenge. This study aimed to investigate the risk factors associated with 30-day mortality in patients diagnosed with S. maltophilia pneumonia. Methods: This retrospective, single-center study included patients aged 18 years and older who were hospitalized between January 2018 and December 2021, had S. maltophilia isolated from respiratory samples, and demonstrated clinical and radiological evidence of pneumonia. Patients were grouped by 30-day survival status, and comparisons were made for demographic characteristics, risk factors, and antibiotic regimens. Results: Among the 200 evaluated patients, colonization was detected in 48%. A total of 104 patients met the inclusion criteria, of whom 75% required ICU admission. The 30-day mortality rate was 55.7%. Malignancies were present in 62.5%. Polymicrobial infections and coinfections were observed in 39.4% and 82.4%, respectively. Multivariate analysis identified SOFA (Sequential Organ Failure Assessment) score (OR = 1.293, 95% CI [1.113-1.501], p = 0.001), mechanical ventilation (OR = 5.005, 95% CI [1.379-18.157], p = 0.014), and a high Charlson Comorbidity Index (OR = 1.353, 95% CI [1.103-1.650], p = 0.004) as independent predictors of mortality. Combination antibiotic therapy had no significant effect on mortality. No resistance to trimethoprim-sulfamethoxazole was detected. Conclusion: S. maltophilia pneumonia is a serious nosocomial infection with high mortality, particularly in ICU patients with malignancies. SOFA score, mechanical ventilation, and a high Charlson Comorbidity Index were independently associated with increased mortality.