The cellular immunity and oxidative stress markers in early pregnancy loss


Daglar K., Biberoglu E., Kirbas A., Dirican A. O. , Genc M., AVCI A., ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.29, no.11, pp.1840-1843, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 11
  • Publication Date: 2016
  • Doi Number: 10.3109/14767058.2015.1064886
  • Title of Journal : JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Page Numbers: pp.1840-1843

Abstract

Objective: We investigated whether changes in cellular immunity and oxidative stress in pregnancy have any association with spontaneous miscarriage.Material and methods: Circulating adenosine deaminase (ADA) activity as a marker of cellular immunity and malondialdehyde (MDA) and catalase (CAT), glutathione peroxidase (GPx) as markers of T lymphocyte activation and parameters of oxidative stress and antioxidant defense were compared between 40 women with early pregnancy loss and another 40 women with ungoing healthy pregnancy.Results: Women with miscarriage had higher serum ADA and GPx levels when compared with women with normal pregnancy (p=0.034 and p<0.001, respectively). Although serum MDA level was slightly higher in women with miscarriage, the difference was not significant (p=0.083). CAT levels were alike in both groups.Conclusion: We have demonstrated an increased cellular immunity and perhaps a compensated oxidative stress related to increased antioxidant activation in women with early spontaneous pregnancy loss.