PVA/PAA/PEG/PVP nanofibers with HPMC and aloe vera were fabricated by electrospinning method. HPMC was added to the hybrid polymer solution as the water retention agent and aloe vera which are known over centuries were also added to the system to promote the healing of wounded or infected skin. The fabricated nanofiber mats were characterized using SEM, DSC, and FT-IR. SEM Images exhibited that the electrospun nanofibers were homogenous and linear. The nanofiber diameters ranged between 80-480 nm.