Akademik Veri Yönetim Sistemi
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, cilt.63, sa.2, ss.160-166, 2025 (SCI-Expanded)
Methomyl (Met) is a widely used carbamate pesticide worldwide. Environmental and occupational exposure to methomyl can cause serious health problems. This study was conducted to determine the possible hepatic toxic effects of methomyl in rats. It is also aimed to contribute to understanding the therapeutic potential of curcumin, a natural antioxidant, against this toxic effect in this study. For this purpose, curcumin (100 mg kg-1 bw), methomyl (0,8 mg kg-1 bw), methomyl + curcumin were given to rats with oral route for 28 days. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) and total protein, albumin, triglyceride, total cholesterol levels in serum and malondialdehyde level (MDA) and activities of antioxidant enzyme (GPx, GST, SOD, CAT) and histopathological alterations in liver tissue were studied. Methomyl caused significantly increment in the AST, ALT, ALP, LDH activities and total cholesterol and MDA levels. However, methomyl induced importantly reducing in the total protein, albumin, triglyceride levels and SOD, CAT, GPx and GST activities. In addition to, degeneration of hepatocytes, congestion and mononuclear cell infiltration in the liver tissue of methomyl-received rats. In addition, co-administration of curcumin with methomyl importantly reduced the toxicity methomyl-caused on the liver function parameters, lipid peroxidation and activities of results showed that curcumin significantly may alleviate methomylinduced hepatoxicity in rats.