Technical Aspects and Difficulties in the Management of Head and Neck Cutaneous Malignancies in Xeroderma Pigmentosum

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ŞİBAR S., FINDIKÇIOĞLU K., Erdal A. I., Barut I., Ozmen S.

ARCHIVES OF PLASTIC SURGERY-APS, cilt.43, sa.4, ss.344-351, 2016 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5999/aps.2016.43.4.344
  • Dergi Adı: ARCHIVES OF PLASTIC SURGERY-APS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.344-351
  • Anahtar Kelimeler: Skin neoplasms, Head and neck neoplasms, Xeroderma pigmentosum, Free tissue flaps, THICKNESS SKIN-GRAFT, MOHS MICROGRAPHIC SURGERY, DNA-REPAIR, COCKAYNE-SYNDROME, DISORDERS, EXCISION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment.