Preparation, characterization and antibacterial activity of the 5-membered ring via Schiff's bases

MUSLIM R. A. S. I. M. F. A. R. R. A. J., MAJEED I. S. M. A. E. E. L. Y. A. S. E. E. N., SALEH S. U. H. E. B. E. A. I. D., SALEH M. A. R. W. A. N. M. A. H. M. O. O. D., OWAID M. U. S. T. A. F. A. N. A. D. H. I. M., ABBAS J. A. L. A. L. A. B. D. U. L. K. A. R. E. E. M.

PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, cilt.15, sa.3, ss.1042-1047, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2021
  • Dergi Adı: PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), EMBASE
  • Sayfa Sayıları: ss.1042-1047
  • Gazi Üniversitesi Adresli: Evet

Özet

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J(1)-J(5) derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. Schiff's bases were synthesis by condensation of primary aromatic amine and aromatic carbonyl compounds. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J(1)-J(5) derivatives. The compounds J(1)-J(5) were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 mu g.well(-1) for J(4) against the two pathogenic bacteria, while J(1), J(4), and J(1) did not show any inhibitory effect against all bacteria. Finally, the 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J(4)) is the best compound synthesized inhibited the growth of gram-negative and positive bacteria.