Preparation, characterization and antibacterial activity of the 5-membered ring via Schiff's bases


MUSLIM R. A. S. I. M. F. A. R. R. A. J. , MAJEED I. S. M. A. E. E. L. Y. A. S. E. E. N. , SALEH S. U. H. E. B. E. A. I. D. , SALEH M. A. R. W. A. N. M. A. H. M. O. O. D. , OWAID M. U. S. T. A. F. A. N. A. D. H. I. M. , ABBAS J. A. L. A. L. A. B. D. U. L. K. A. R. E. E. M.

PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, vol.15, no.3, pp.1042-1047, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2021
  • Journal Name: PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), EMBASE
  • Page Numbers: pp.1042-1047
  • Gazi University Affiliated: Yes

Abstract

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J(1)-J(5) derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. Schiff's bases were synthesis by condensation of primary aromatic amine and aromatic carbonyl compounds. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J(1)-J(5) derivatives. The compounds J(1)-J(5) were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 mu g.well(-1) for J(4) against the two pathogenic bacteria, while J(1), J(4), and J(1) did not show any inhibitory effect against all bacteria. Finally, the 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J(4)) is the best compound synthesized inhibited the growth of gram-negative and positive bacteria.