Effects of PPAR gamma and PPAR alpha agonists on serum leptin levels in diet-induced obese rats


Toruner F. S., Akbay E., Cakir N., Sancak B., Elbeg S., Taneri F., ...Daha Fazla

HORMONE AND METABOLIC RESEARCH, cilt.36, sa.4, ss.226-230, 2004 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2004
  • Dergi Adı: HORMONE AND METABOLIC RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.226-230
  • Anahtar Kelimeler: diet-induced obesity, leptin, rosiglitazone, gemfibrozil, PPAR, OB GENE-EXPRESSION, INSULIN-RESISTANCE, ADIPOSE-TISSUE, BRL 49653, FAT, THIAZOLIDINEDIONES, ROSIGLITAZONE, FENOFIBRATE, SENSITIVITY, ACTIVATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Leptin and peroxisome proliferator-activated receptors are two important adipose tissue factors involved in energy metabolism regulation. It has been shown that PPARgamma agonists decrease leptin levels. However, the effects of PPARalpha agonists on leptin have not been investigated much. The aim of this study was to compare the effects of a PPARgamma agonist rosiglitazone (RSG) and PPARalpha agonist gemfibrozil (G) on body weight and serum insulin and leptin levels in diet-induced obese rats. Male Wistar rats were divided into six groups according to diet and drug therapy. After four weeks, serum glucose, triglyceride, insulin and leptin levels were significantly decreased in the high-fat-fed and RSG-treated groups compared to the group fed a high-fat diet only (162 +/- 19 vs. 207 +/- 34 mg/dl, 58 +/- 20 vs. 112 +/- 23 mg/d;, 3.1 +/- 1.0 vs. 15.2 +/- 4.0 ng/ml, 1.6 +/- 0.5 vs. 3.6 +/- 1.6 ng/ml, respectively). However, these parameters were not statistically different in RSG animals treated with a standard diet compared to the standard diet group. The high fat+RSG group gained much more weight compared to high-fat and high-fat+G groups (p > 0.05). Additionally, serum glucose, insulin and leptin levels were significantly decreased in the high-fat-fed and G-treated group compared to high-fat group (149 19 vs. 207 34 mg/dl, 57 16 vs. 112 +/- 23mg/dl, 4.3 +/- 2.1 vs. 15.2 +/- 4.0 ng/ml, 1.6 +/-0.4 vs. 3.6 +/- 1.6 ng/ml, respectively). These results suggest that PPARalpha agonists may decrease serum glucose, insulin and leptin levels as PPARgamma agonists do in diet-induced obese rats.