Elevated Levels of Circulating Angiotensin Converting Enzyme in Patients with Hepatoportal Sclerosis


BEYAZIT Y., Ibis M., Purnak T., Turhan T., KEKİLLİ M., Kurt M., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.56, no.7, pp.2160-2165, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1007/s10620-011-1580-7
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2160-2165
  • Keywords: Hepatoportal sclerosis, Angiotensin converting enzyme, renin-angiotensin system, Pathogenesis, IDIOPATHIC PORTAL-HYPERTENSION, LIVER-TRANSPLANTATION, HEPATITIS-C, SYSTEM, RENIN, CIRRHOSIS, FIBROSIS, INHIBITION, HEMOSTASIS, VENOPATHY
  • Gazi University Affiliated: No

Abstract

Hepatoportal sclerosis (HPS) is a clinicopathologic condition that is clinically characterized by portal hypertension (varices and portosystemic collateral vessels), splenomegaly and pancytopenia, in the absence of cirrhosis. Although the etiology is obscure, a number of theories such as immunologic and vascular endothelial cellular abnormalities have been put forward to explain the underlying pathophysiology. Angiotensin-converting enzyme (ACE), an important molecule of the renin-angiotensin system (RAS), is also known as a regulatory molecule in systemic and portal circulation in distinct disorders. The aim of the present study was to investigate the possible role of the ACE in the context of RAS in HPS pathogenesis.