Does single cortical spreading depression elicit pain behaviour in freely moving rats?


Akcali D. , Sayin A., Sara Y., Bolay H.

CEPHALALGIA, cilt.30, ss.1195-1206, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/0333102409360828
  • Dergi Adı: CEPHALALGIA
  • Sayfa Sayıları: ss.1195-1206

Özet

Introduction: Behavioural animal studies are critical, particularly to translate results to human beings. Cortical spreading depression (CSD) has been implicated in migraine pathogenesis. We aimed to investigate the effects of CSD on the behaviour of freely moving rats, since available CSD models do not include awake animals.