Does single cortical spreading depression elicit pain behaviour in freely moving rats?

Akcali D., Sayin A., Sara Y., Bolay H.

CEPHALALGIA, cilt.30, sa.10, ss.1195-1206, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/0333102409360828
  • Dergi Adı: CEPHALALGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1195-1206
  • Anahtar Kelimeler: behaviour, cortical spreading depression, migraine, rat, sumatriptan, TRIGEMINAL NUCLEUS CAUDALIS, METHYL-D-ASPARTATE, ULTRASONIC VOCALIZATION, MIGRAINE, MECHANISMS, AMYGDALA, VALIDATION, LABORAS(TM), EXPRESSION, ISCHEMIA
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Behavioural animal studies are critical, particularly to translate results to human beings. Cortical spreading depression (CSD) has been implicated in migraine pathogenesis. We aimed to investigate the effects of CSD on the behaviour of freely moving rats, since available CSD models do not include awake animals.