Does single cortical spreading depression elicit pain behaviour in freely moving rats?


Akcali D. , Sayin A., Sara Y., Bolay H.

CEPHALALGIA, vol.30, no.10, pp.1195-1206, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.1177/0333102409360828
  • Title of Journal : CEPHALALGIA
  • Page Numbers: pp.1195-1206

Abstract

Introduction: Behavioural animal studies are critical, particularly to translate results to human beings. Cortical spreading depression (CSD) has been implicated in migraine pathogenesis. We aimed to investigate the effects of CSD on the behaviour of freely moving rats, since available CSD models do not include awake animals.