Protective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study

Eser A., Hizli D., Namuslu M., Haltas H., Kosus N., Kosus A., ...More

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, vol.44, no.3, pp.453-457, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.12891/ceog3235.2017
  • Page Numbers: pp.453-457


Purpose of investigation: To determine the protective effect of curcumin on ovarian reserve in a rat ischemia model. Materials and Methods: Thirty female Albino rats were randomly divided into two groups by time of unilateral, left ovary ischemia/reperfusion (group 1: two-hour ischemia / two-hour reperfusion; group 2: four-hour ischemia / four-hour reperfusion). Each group was subdivided into three subgroups, sham, control, and curcumin (intraperitoneal curcumin (200 mg/kg) simultaneously with reperfusion). Histological grading of ischemic indices of paraffin-embedded ovarian tissue using hematoxylin and eosin (H&E), and anti-Mullerian hormone (AMH) levels by enzyme-linked immunosorbent assay (ELISA), were measured 40 days later. Results: No difference was found between groups 1 and 2 or among subgroups within either group for right and left ovary grades. AMH levels were significantly higher in the curcumin subgroup compared to sham and control within group 2 and in group 2 versus group 1 curcumin subgroups. Conclusion: Curcumin maintains and protects ovarian functions in an ischemia-reperfusion rat model.