Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury


Yilmaz T. U. , YAZIHAN N., Dalgic A., Kaya E. E. , Salman B., Kocak M., ...More

INDIAN JOURNAL OF MEDICAL RESEARCH, vol.141, pp.807-815, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 141
  • Publication Date: 2015
  • Doi Number: 10.4103/0971-5916.160713
  • Journal Name: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.807-815
  • Keywords: Diazoxide, erythropoietin, glinbenclamide, hypoxia inducible factor-1 alpha, KATP channels, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, SIGNALING PATHWAYS, MECHANISMS, KIDNEY, CARDIOPROTECTION, INFLAMMATION, PROTECTS, CELLS, HEART
  • Gazi University Affiliated: No

Abstract

Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.