Copy For Citation
Yilmaz T. U., YAZIHAN N., Dalgic A., Kaya E. E., Salman B., Kocak M., ...More
INDIAN JOURNAL OF MEDICAL RESEARCH, vol.141, pp.807-815, 2015 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
141
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Publication Date:
2015
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Doi Number:
10.4103/0971-5916.160713
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Journal Name:
INDIAN JOURNAL OF MEDICAL RESEARCH
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.807-815
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Keywords:
Diazoxide, erythropoietin, glinbenclamide, hypoxia inducible factor-1 alpha, KATP channels, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, SIGNALING PATHWAYS, MECHANISMS, KIDNEY, CARDIOPROTECTION, INFLAMMATION, PROTECTS, CELLS, HEART
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Gazi University Affiliated:
No
Abstract
Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.