Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury

Yilmaz T. U., YAZIHAN N., Dalgic A., Kaya E. E., Salman B., Kocak M., ...Daha Fazla

INDIAN JOURNAL OF MEDICAL RESEARCH, cilt.141, ss.807-815, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 141
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0971-5916.160713
  • Dergi Adı: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.807-815
  • Anahtar Kelimeler: Diazoxide, erythropoietin, glinbenclamide, hypoxia inducible factor-1 alpha, KATP channels, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, SIGNALING PATHWAYS, MECHANISMS, KIDNEY, CARDIOPROTECTION, INFLAMMATION, PROTECTS, CELLS, HEART
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.