Akademik Veri Yönetim Sistemi
The European Federatıon For Experımental Morphology (EFEM), (Fırst European Student Symposıum On Anatomıcal Research), Dublin, İrlanda, 27 - 28 Nisan 2022
Our aim in our study was to examine the effects of transauricular vagal stimulation on synapse formation and intestinal morphometry in the enteric nervous system in rats with experimental colitis.
Colitis was induced by intracolonic instillation of trinitrobenzene sulfonic acid (TNBS). Saline was injected into the control groups. Animals were weighed before induction of saline and TNBS at the end of the experiment. Vagus nerve stimulation was performed in animals for 30 minutes, 2 times a day for ten consecutive days. Inflammation in the colon was evaluated by body weight, macroscopic (area of lesions), histological and immunohistochemical analyses, pathological changes and immunoreactivity of IL-1β, IL-6, IL-10 and TNFα. Vagus nerve stimulation reduced the degree of body weight loss and inflammatory markers, as observed above the lesion by histological score.
The anti-inflammatory properties of vagus nerve stimulation have been reported in various experimental models of inflammation, but there has been no study of transauricular vagus nerve stimulation in the experimental colitis model. The concept of electrically stimulating the auricular branch of the vagus nerve, which provides the superficial sensory innervation of the outer ear, is relatively new compared to cervical vagus nerve stimulation. There is a lack of literature on this subject. In line with this need, we carried out our study with transauricular nervus vagus stimulation in rats.