Serum gamma glutamyl transferase and alanine transaminase concentrations predict endothelial dysfunction in patients with non-alcoholic steatohepatitis


Arinc H., Sarli B., Baktir A. O., Saglam H., Demirci E., Dogan Y., ...More

Upsala Journal of Medical Sciences, vol.118, no.4, pp.228-234, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3109/03009734.2013.814734
  • Journal Name: Upsala Journal of Medical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.228-234
  • Keywords: Alanine transaminase, Endothelial dysfunction, Gamma glutamyl transferase, Non-alcoholic steatohepatitis
  • Gazi University Affiliated: Yes

Abstract

Purpose. Cardiovascular diseases are the leading cause of death in patients with non-alcoholic steatohepatitis (NASH). We aimed to investigate the presence of endothelial dysfunction and whether serum concentrations of liver enzymes may reflect the severity of such an endothelial dysfunction in patients with NASH. Methods. Fifty patients with NASH diagnosed by liver biopsies and 30 healthy controls were included. Blood samples after fasting were harvested for measurements of glucose, insulin, cholesterol, triglyceride, and liver enzymes. All patients underwent transthoracic echocardiography and brachial and carotid artery Doppler ultrasonography to evaluate flow-mediated dilatation (FMD) and carotid artery intima-media thickness (CIMT). Results. Patients with NASH had impaired FMD (4.9 ± 2.8% to 9.3 ± 4.4%, P < 0.001) and higher CIMT (0.79 ± 0.16 mm to 0.64 ± 0.11 mm, P < 0.001) when compared with healthy controls. Linear regression analyses revealed that serum concentrations of gamma glutamyl transferase (GGT) and alanine transaminase (ALT) were associated with FMD and CIMT. Conclusions. Patients with NASH have impaired FMD and increased CIMT when compared with healthy controls. In patients with NASH, serum concentrations of GGT and ALT might have a predictive value for FMD and CIMT. © 2013 Informa Healthcare.