Akademik Veri Yönetim Sistemi
Türk Nöroradyoloji Derneği Ulusal 32. Yıl Kongresi, İstanbul, Türkiye, 24 - 26 Mart 2023
Introduction: Neurofibromatosis type 1 (NF1) is characterized
by focal T2 hyperintense brain lesions that are predominantly located in the deep gray nuclei, brainstem, and cerebellar white matter.
This study explored the existence of volume differences in the hippocampus of the NF1 subjects without a history of epilepsy.
Materials and Methods: In this retrospective study, by using
three-dimensional T1-weighted MR images, 16 patients with NF1
and 14 age and gender-matched healthy control subjects were
quantitatively assessed. According to age and sex, measurements
and evaluations of the hippocampus were performed with volBrain
software (Fig 1).
Results: The study included 16 (%53.3) NF1 patients, with
31.3% males and 68.8% females, with a mean age of 12.56 ± 4.76
years (range, 4- 19 years). The control group included 14 age- and
gender-matched healthy people with 35.7% males and 64.3% females, a mean age of 11.86 ± 4.17 years (range, 5- 17 years). Tables
1 show the demographic and clinical characteristics of NF1 patients
and the healthy control group. The groups did not differ significantly
in terms of age, or gender (p>0.05).
The total hippocampal volume was found to be significantly higher in the NF1 patient group than in the healthy control group (Table
1) (p=0.001). In addition, right and left hippocampal volumes were
significantly higher in the NF1 patient group than in the healthy control group (p<0.001 and p=0.017, respectively).
Table 2 shows the results of the ROC analysis. Total hippocampus
volume showed good diagnostic performance in differentiating NF1
patients. The AUC value for total hippocampal volume was 0.830
(P=0.001), with a sensitivity of 81.3% and a specificity of 78.6% at
a cutoff value of 96.95.
Conclusion: Neuroanatomic abnormalities in specific brain
regions have previously been observed in NF1(1,2). Quantitative
measurements by MRI may be biomarkers for longitudinal investigation in morphology and volume in selected cortical and subcortical
structures in NF1 patients. We have identified that volumes of hippocampi both in right and left hemispheres are significantly larger in
patients with NF1 in comparison to healthy controls.
Keywords: Neurofibromatosis type 1, Hippocampus volume, Subcortical
analysis