Hereditary multiple exostoses an autosomal dominant skeletal disorder characterized by multiple cartilage-capped benign exostoses that typically occur in the metaphysis of long bones. The prevalence of hereditary multiple exostoses is estimated to be 1 in 50,000. Although, there have been many studies concerning this rare disorder, no research has yet examined the rehabilitation of hereditary multiple exostoses. The case diagnosed with hereditary multiple exostoses referred to our department with several complaints, namely pain, joint limitations, muscle weakness, and functional insufficiency after arthroscopic distal left femur exostoses excision. The aim of this case report was to present effectiveness of eccentric training as an adjunct to rehabilitation program for hereditary multiple exostoses. According to the results, eccentric training after arthroscopic exostoses excision may help reduce pain, increase range of motion, muscle strength, and functional levels in patients with hereditary multiple exostoses.