Persistence of cardiovascular risk factors in women with previous preeclampsia: A long-term follow-up study


Aykas F., Solak Y., Erden A., Bulut K., Dogan S., Sarli B., ...Daha Fazla

Journal of Investigative Medicine, cilt.63, sa.4, ss.641-645, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/jim.0000000000000189
  • Dergi Adı: Journal of Investigative Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.641-645
  • Anahtar Kelimeler: cardiovascular disease, endothelial dysfunction, microalbuminuria, preeclampsia, risk factor, uric acid
  • Gazi Üniversitesi Adresli: Hayır

Özet

© Lippincott Williams & Wilkins.Background: Preeclampsia is a cardiovascular (CV) disease risk factor, and lifestyle modifications are recommended. It was suggested that preeclampsiamay increase the prevalence of variousCVdisease risk factors such as metabolic syndrome, hypertension, insulin resistance, microalbuminuria, and endothelial dysfunction, among others. Here, we investigate the role of serumuric acid in preeclampsia in the development of CVcomplications. Materials andMethods: This was an observational case-control study that compared women with history of preeclampsia (n = 25) with agematched controls with uncomplicated pregnancies (n = 20) who were followed for at least 5 years. Measurements included clinical and ambulatory blood pressure monitoring, ultrasound-measured flow-mediated dilatation (FMD), microalbuminuria, carotid intima-media thickness (CIMT) and serum uric acid, as well as clinical and demographic features. Cardiovascular disease risk factors were compared in women with and without previous preeclampsia. Results: At the time of index gestation, preeclamptic women had higher serum uric acid values (4.360.61 vs 2.27 0.38 mg/dL, P < 0.001). Five years after pregnancy, the patients who had preeclampsia were more likely to have hypertension and had higher serum uric acid levels, higher microalbuminuria and CIMT levels, and lower FMD values than did the patientswho did not have preeclampsia. The 2 groups were similar with regard to various ambulatory blood pressure parameters. Univariate associates of FMD were history of preeclampsia and the current hypertension status. Microalbuminuria correlated with gestational uric acid levels (coefficient of correlation of 0.40, P = 0.01 for FMD and coefficient of correlation of 0.37, P = 0.01 for CIMT, respectively). Conclusions: Preeclampsia might be a risk factor for the development of cardiovascular risk factors at least 5 years after index pregnancy. Serum uric acid and microalbuminuria may be mechanistic mediators of heightened risk, along with impaired endothelial function in preeclampsia.