Structure-activity relationships of imperialine derivatives and their anticholinergic activity

Atta-ur-Rahman A., Choudhary M., Farooq A., Anjum S., Baumgold J., Sener B.

PLANTA MEDICA, cilt.64, sa.2, ss.172-174, 1998 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 64 Sayı: 2
  • Basım Tarihi: 1998
  • Dergi Adı: PLANTA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.172-174
  • Gazi Üniversitesi Adresli: Hayır

Özet

In order to check the structure-activity relationship and prepare more potent derivatives of imperialine with anticholinergic activity, imperialinol (2), 3 beta-acetoxyimperialine (3), 3 beta-propionoxyimperialine (4), and 3 beta-butyroxyimperialine (5) were prepared. Compounds 4 and 5 displayed better anticholinergic activity against muscarinic receptors of the heart and brain than imperialine (1). The decrease in activity in 2 showed the importance of the 6-keto functionality in imparting the anticholinergic activity.