Synthesis and antinociceptive activity of some 1-phenyl-2-(2-benzothiazolinone-3-yl) ethanones and their reduced derivatives

Cakir B., Dogruer S. , Yesilada E. , ŞAHİN M. G.

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.14, sa.2, ss.92-98, 1997 (Diğer Kurumların Hakemli Dergileri) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Konu: 2
  • Basım Tarihi: 1997
  • Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Sayfa Sayıları: ss.92-98


Ten 2-benzothiazolinone derivatives have been synthesized and their structure have been elucidated by IR, 1H NMR spectral data and elemental analyses. Antinociceptive activity of the compounds has been investigated by modified Koster test in mice using aspirin as a reference. The reduced ethanol derivatives have been found more active than corresponding ethanones.