EXAMİNATION OF THE RELATIONSHIP BETWEEN FECAL CALPROTECTIN AND FECAL OCCULT BLOOD


Creative Commons License

Ünal K.

TBS INTERNATIONAL BIOCHEMISTRY CONGRESS 2022 33RD NATIONAL BIOCHEMISTRY CONGRESS, İzmir, Turkey, 26 - 30 October 2022, pp.72

  • Publication Type: Conference Paper / Summary Text
  • City: İzmir
  • Country: Turkey
  • Page Numbers: pp.72
  • Gazi University Affiliated: Yes

Abstract

BACKGROUND AND AIM: Fecal calprotectin (FC) is used to evaluate intestinal mucosal inflammation.The fecal occult blood (FOB) is used for detecting of invisible blood in stool. There are publications that the combined use of FC and FOB may be helpful in the diagnosis of some intestinal diseases, but also there are studies showing that gastrointestinal bleeding may cause high FC. The aim of this study is to examine the relationship between these two parameters in patients who have synchronous FC and FOB. MaterialMATERIALS and METHODS: 182 patients who had synchronous FC and FOB tests were included in the study, the data of the patients were analyzed retrospectively. RESULTS: The patients with positive FOB comprised 44% of all patients (Group 1, n:78). The patients with negative FOB comprised 56% of all patients (Group 2, n:102). These groups were compared in terms of FC, group 1 (410 µg/g (30-1000)) FC levels were statistically higher than group 2 (70 µg/g ( 30-1000)) (p<0.05). 40% consisted of inflammatory bowel disease and 60% consisted of functional bowel diseases such as irritable bowel syndrome in this study. When the relationship between FOB positivity and FC according to grouping the diseases was examined, significant correlation was found between two parameters in both diseases (r:0.525, p<0.05). CONCLUSION: FOB positivity may be late sign of inflammatory tissue damage. FC values above 80 µg/g may be an indicator of inflammation in the gastrointestinal tract, but there are some conditions that may affect. More studies are needed to show that FOB positivity can increase FC. Keywords: Fecal calprotectin, fecal occult blood, inflammatory bowel disease, irritable bowel syndrome