TBS INTERNATIONAL BIOCHEMISTRY CONGRESS 2022 33RD NATIONAL BIOCHEMISTRY CONGRESS, İzmir, Turkey, 26 - 30 October 2022, pp.72
BACKGROUND AND AIM: Fecal calprotectin (FC) is used to
evaluate intestinal mucosal inflammation.The fecal occult blood
(FOB) is used for detecting of invisible blood in stool. There are
publications that the combined use of FC and FOB may be helpful in the diagnosis of some intestinal diseases, but also there are
studies showing that gastrointestinal bleeding may cause high FC.
The aim of this study is to examine the relationship between these
two parameters in patients who have synchronous FC and FOB.
MaterialMATERIALS and METHODS: 182 patients who had synchronous
FC and FOB tests were included in the study, the data of the patients were analyzed retrospectively.
RESULTS: The patients with positive FOB comprised 44% of all
patients (Group 1, n:78). The patients with negative FOB comprised 56% of all patients (Group 2, n:102). These groups were compared in terms of FC, group 1 (410 µg/g (30-1000)) FC levels were
statistically higher than group 2 (70 µg/g ( 30-1000)) (p<0.05).
40% consisted of inflammatory bowel disease and 60% consisted of functional bowel diseases such as irritable bowel syndrome
in this study. When the relationship between FOB positivity and
FC according to grouping the diseases was examined, significant
correlation was found between two parameters in both diseases
CONCLUSION: FOB positivity may be late sign of inflammatory
tissue damage. FC values above 80 µg/g may be an indicator of
inflammation in the gastrointestinal tract, but there are some conditions that may affect. More studies are needed to show that FOB
positivity can increase FC.
Keywords: Fecal calprotectin, fecal occult blood, inflammatory
bowel disease, irritable bowel syndrome