TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.2, pp.167-173, 2008 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF MEDICAL SCIENCES
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
degradation and impurity products, acetylsalicylic acid, paracetamol, salicylic acid, p-chloroacetanilide, HPLC, PERFORMANCE LIQUID-CHROMATOGRAPHY, SPECTROPHOTOMETRIC DETERMINATION, MULTIPARAMETER SENSOR, SALICYLIC-ACID, ACETAMINOPHEN, CAFFEINE, TABLETS, MIXTURES, ASSAY, SPECTROSCOPY
Gazi University Affiliated:
Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and degradation products during pharmaceutical development is necessary because of their potential toxicity. The aim of this study was to develop a rapid and simultaneous determination method for paracetamol and acetylsalicylic acid (ACA) and their degradation and toxic impurity products by high performance liquid chromatography (HPLC) in pharmaceutical dosage forms.