Copy For Citation
Akay C., Degim I. T., Sayal A., Aydin A., Ozkan Y., Gul H.
TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.2, pp.167-173, 2008 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
38
Issue:
2
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Publication Date:
2008
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Journal Name:
TURKISH JOURNAL OF MEDICAL SCIENCES
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Page Numbers:
pp.167-173
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Keywords:
degradation and impurity products, acetylsalicylic acid, paracetamol, salicylic acid, p-chloroacetanilide, HPLC, PERFORMANCE LIQUID-CHROMATOGRAPHY, SPECTROPHOTOMETRIC DETERMINATION, MULTIPARAMETER SENSOR, SALICYLIC-ACID, ACETAMINOPHEN, CAFFEINE, TABLETS, MIXTURES, ASSAY, SPECTROSCOPY
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Gazi University Affiliated:
Yes
Abstract
Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and degradation products during pharmaceutical development is necessary because of their potential toxicity. The aim of this study was to develop a rapid and simultaneous determination method for paracetamol and acetylsalicylic acid (ACA) and their degradation and toxic impurity products by high performance liquid chromatography (HPLC) in pharmaceutical dosage forms.