Aim: The aim of this study was to evaluate the protective effects of dietary syringic acid (SA) on the development and severity of cerulein-induced acute pancreatitis (AP) in rats in terms of biochemical and histopathologic changes. Material and Method: 24 rats were divided into 3 equal groups. Three groups were compared in terms of the levels of oxidative stress, antioxidant markers, pancreatic enzymes, and histopathological changes. This study was approved by the ethics committee of our university and the project was supported by the scientific research unit (project number 2016 / 3-43 D). Results: In the pancreatitis group, the amylase and lipase values were significantly higher and oxidative stress markers were significantly elevated; the Glutathione peroxidase (GSH-Px) level was found to be significantly decreased in the pancreatitis group compared to the control and treatment groups. Apoptosis and cellular damage level results were significantly higher in the pancreatitis group, while cellular damage in the treatment group was significantly lower (P < 0.05) than in the pancreatitis group. Discussion: Although a syringic acid diet does not totally prevent AP, it has been shown to decrease the severity of AP on both enzymatic and histopathological levels.