To evaluate the influence of different materials on the load-bearing-capacity of inlay-retained fixed-dental-prosthesis (FDP). Ten types of FDPs were evaluated (n=7/group): Group PEEK: CAD-CAM polyetheretherketone (PEEK-TechnoMed), Group RC, made of discontinuous-fiber-composite (EverX Posterior); Group FRC1, made of discontinuous-fiber-composite (EverX Posterior) with two-bundles of continuous-unidirectional fiber-reinforced-composite (FRC) (Everstick C & Group FRC2, made of discontinuous fiber-composite (EverX Posterior) with two-bundles of continuous-unidirectional-FRC (Everstick C&B) covered by two-pieces of short-unidirectional-FRC (Everstick C&B) placed perpendicular to the main-framework; Group FB, CAD-CAM fiber-block (Fibra-Composite Bio-C); Group PMMA, CAD-CAM polymethyl methacrylate block (Temp basic); Group RP, resin-paste; Group FRP1, made of resin-paste (G-Fix) with two-bundles of continuous-unidirectional-FRC (Everstick C & Group FRP2, made of resin-paste (G-Fix) two-bundles of continuous-unidirectional-FRC covered by two-pieces of short unidirectional-FRC placed perpendicular to the main framework and Group exp-FRC, experimental CAD-CAM FRC. The bridges were statically-loaded until fracture. Fracture modes were visually examined. ANOVA revealed that significant differences were observed between FDP-materials (p<0.05). In addition, fiber addition to the framework significantly affected load-bearing-capacity (p<0.05).