The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa.

Gonul B., Akbulut K. G. , Ozer Ç. , Yetkin G., Celebi N.

Surgery today, vol.34, no.12, pp.1035-40, 2004 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 12
  • Publication Date: 2004
  • Doi Number: 10.1007/s00595-004-2856-8
  • Title of Journal : Surgery today
  • Page Numbers: pp.1035-40


Purpose. Transforming growth factor (TGF) alpha accelerates wound healing, especially in gastric ulcers. Transforming growth factor alpha can be affected by acid and pepsin in the gastric juice. Oxidative stress also plays a role in the formation of gastric lesions. This study was designed ( 1) to investigate the effects of microemulsion dosage form on the healing of gastric ulcers, and ( 2) to determine the relationship between oxidative mechanisms and TGF-alpha during ulcer healing.