The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa

Gonul B., Akbulut K., Ozer C., Yetkin G., Celebi N.

SURGERY TODAY, cilt.34, ss.1035-1040, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/s00595-004-2856-8
  • Dergi Adı: SURGERY TODAY
  • Sayfa Sayıları: ss.1035-1040


Purpose. Transforming growth factor (TGF) alpha accelerates wound healing, especially in gastric ulcers. Transforming growth factor alpha can be affected by acid and pepsin in the gastric juice. Oxidative stress also plays a role in the formation of gastric lesions. This study was designed ( 1) to investigate the effects of microemulsion dosage form on the healing of gastric ulcers, and ( 2) to determine the relationship between oxidative mechanisms and TGF-alpha during ulcer healing.