Bariatric Surgery in Obesity: Metabolic Quality Analysis and Comparison of Surgical Options

ENGİN A.

Advances in experimental medicine and biology, vol.1460, pp.697-726, 2024 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1460
  • Publication Date: 2024
  • Doi Number: 10.1007/978-3-031-63657-8_24
  • Journal Name: Advances in experimental medicine and biology
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.697-726
  • Keywords: Adiponectin, Anemia, Apelin, Bariatric surgery, C-reactive protein, Endothelial nitric oxide synthase (eNOS), Ghrelin, Glutathione, Homocysteine, Inducible nitric oxide synthase (iNOS), Insulin resistance, Interleukin-6 (IL-6), Leptin, Lysyl oxidase (LOX), Obesity, Oxidative stress, Resistin, Retinol-binding protein-4 (RBP4), Roux-en-Y gastric bypass, Sleeve gastrectomy, Total cysteine (tCys), Triglycerides, Vaspin, Visfatin, Weight loss
  • Gazi University Affiliated: Yes

Abstract

Obesity is a constantly growing health problem which reduces quality of life and life expectancy. Bariatric surgery (BS) for obesity is considered when all other conservative treatment modalities have failed. Comparison of the multidisciplinary programs with BS regarding to the weight loss showed that substantial and durable weight reduction have been achieved only with bariatric surgical treatments. Although laparoscopic sleeve gastrectomy is the most popular BS, it has high long-term failure rates, and it is claimed that one of every three patients will undergo another bariatric procedure within a 10-year period. Although BS provides weight loss and improvement of metabolic comorbidities, in long-term follow-up, weight gain is observed in half of the patients, while decrease in bone mass and nutritional deficiencies occur in up to 90%. Moreover, despite significant weight loss, several psychological aspects of patients are worsened in comparison to preoperative levels. Nearly one-fifth of postoperative patients with "Loss-of-eating control" meet food addiction criteria. Therefore, the benefits of weight loss following bariatric procedures alone are still debated in terms of the proinflammatory and metabolic profile of obesity.