THE ROLE OF PROSTANOIDS IN THE COMPLICATIONS OF EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY (ESWL) IN CHILDREN


HASANOGLU E., BUYAN N., BOZKIRLI I., ERCAN S.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol.51, no.5, pp.381-384, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 1994
  • Doi Number: 10.1016/0952-3278(94)90012-4
  • Title of Journal : PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Page Numbers: pp.381-384

Abstract

ESWL is a safe and effective first-line treatment for urinary tract stone disease (UTSD) in children. The major complications arising from this procedure were upper urinary tract obstruction and ureteral colic. It was shown that prostaglandin synthetase inhibitors were effective in the treatment of urethral colic. The aim of this study was to measure urinary and plasma prostaglandin E(2) (PGE(2))- and leukotriene C-4 (LTC(4))-like activity in the patients who underwent ESWL before and after the treatment and investigate the role of cyclooxygenase (CO) and lipoxygenase (LO) products in early and late complications of ESWL. Urinary PGE(2)-like activity were increased 1 h after ESWL. (1.19 +/- 0.12 vs 1.59 +/- 0.15 g/ml, p < 0.02). The plasma values were decreased significantly after the treatment (16.7 +/- 1.7 vs 11.6 +/- 1.2 g/ml, p < 0.005).