Effects of nitric oxide donor and inhibitor on prostaglandin E-2-like activity, malondialdehyde and reduced glutathione levels after skeletal muscle ischemia-reperfusion

Sayan, H; Babul, A; Ugurlu, B

doi:10.1054/plef.2001.0308

Effects of nitric oxide donor and inhibitor on prostaglandin E-2-like activity, malondialdehyde and reduced glutathione levels after skeletal muscle ischemia-reperfusion

Atıf İçin Kopyala

Sayan H., Babul A., Ugurlu B.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.65, sa.4, ss.179-183, 2001 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 65 Sayı: 4
Basım Tarihi: 2001
Doi Numarası: 10.1054/plef.2001.0308
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.179-183
Gazi Üniversitesi Adresli: Hayır

Özet

Oxygen free radicals are implicated in the pathophysiology of ischemia-reperfusion (I/R) injury in skeletal muscle. Nitric oxide (NO) and prostaglandin E-2 (PGE(2)) are important regulators of the microcirculation in skeletal muscle. The effects of L-arginine, substrate for NO, and NG-nitro L-arginine methyl ester (L-NAME) on PGE2 synthesis, lipid peroxidation and reduced glutathione (GSH) levels was investigated in the rat gastrocnemius muscle after 3 h of reperfusion following 2 h of ischemia. Lipid peroxidation and GSH levels showed a non-significant changes in the I/R groups compared to the control group. According to these results, it can be assumed that skeletal muscle can resist 2 h of ischemia followed by 3 h of reperfusion-induced oxidative stress.