Intravitreal dexamethasone implant as an option for anti-inflammatory therapy of tuberculosis uveitis


Hasanreisoglu M., Ikiz G. G. , AKTAŞ Z. , ÖZDEK Ş.

INTERNATIONAL OPHTHALMOLOGY, vol.39, no.2, pp.485-490, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 39 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1007/s10792-018-0831-4
  • Title of Journal : INTERNATIONAL OPHTHALMOLOGY
  • Page Numbers: pp.485-490
  • Keywords: Tuberculosis, Granuloma, Uveitis, Infectious, Posterior uveitis, Jarisch-Herxheimer reaction, Dexamethasone implant, Intravitreal, MANAGEMENT, EFFICACY, SAFETY

Abstract

Introduction Tuberculosis-associated uveitis remains a diagnostic and therapeutic challenge. After diagnosis of tuberculosis and initiation of anti-tuberculosis therapy for tuberculosis uveitis, the clinical responses are favorable. However, at 4-6 weeks of the therapy, there commonly occurs paradoxical deterioration due to an increase in inflammation which is often accompanied by cystoid macular edema. Thus, adjuvant administration of anti-inflammatory regimen should be considered. For this purpose, systemic and periocular steroids, systemic and intravitreal immunosuppressive agents have been tested. Nevertheless, there is no report in the literature about intravitreal dexamethasone slow-release implants for the treatment of this inflammatory condition.Methods Case presentation.ResultsWe presented a tuberculosis uveitis case whose ocular inflammation is partially modified by systemic and periocular steroid injections and then well controlled by the intravitreal dexamethasone implant.ConclusionIntravitreal dexamethasone implant injection seems to be a safe and potent option for the treatment of macular edema secondary to tuberculosis uveitis.