Intravitreal dexamethasone implant as an option for anti-inflammatory therapy of tuberculosis uveitis

Hasanreisoglu M., Ikiz G. G., AKTAŞ Z., ÖZDEK Ş.

INTERNATIONAL OPHTHALMOLOGY, cilt.39, sa.2, ss.485-490, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s10792-018-0831-4
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.485-490
  • Anahtar Kelimeler: Tuberculosis, Granuloma, Uveitis, Infectious, Posterior uveitis, Jarisch-Herxheimer reaction, Dexamethasone implant, Intravitreal, MANAGEMENT, EFFICACY, SAFETY
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction Tuberculosis-associated uveitis remains a diagnostic and therapeutic challenge. After diagnosis of tuberculosis and initiation of anti-tuberculosis therapy for tuberculosis uveitis, the clinical responses are favorable. However, at 4-6 weeks of the therapy, there commonly occurs paradoxical deterioration due to an increase in inflammation which is often accompanied by cystoid macular edema. Thus, adjuvant administration of anti-inflammatory regimen should be considered. For this purpose, systemic and periocular steroids, systemic and intravitreal immunosuppressive agents have been tested. Nevertheless, there is no report in the literature about intravitreal dexamethasone slow-release implants for the treatment of this inflammatory condition.Methods Case presentation.ResultsWe presented a tuberculosis uveitis case whose ocular inflammation is partially modified by systemic and periocular steroid injections and then well controlled by the intravitreal dexamethasone implant.ConclusionIntravitreal dexamethasone implant injection seems to be a safe and potent option for the treatment of macular edema secondary to tuberculosis uveitis.