Clinical phenotype of hereditary spastic paraplegia due to KIF1C gene mutations across life span

Yucel-Yilmaz D., YÜCESAN E., YALNIZOĞLU D., Oguz K. K., Sagiroglu M. S., ÖZBEK U., ...Daha Fazla

BRAIN & DEVELOPMENT, cilt.40, sa.6, ss.458-464, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.braindev.2018.02.013
  • Dergi Adı: BRAIN & DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.458-464
  • Anahtar Kelimeler: KIFIC, Hereditary spastic paraplegia, Ataxia, Kinesin, MECHANISMS, DISORDERS
  • Gazi Üniversitesi Adresli: Hayır

Özet

Hereditary spastic paraplegias (HSPs) are a group of genetic disorders resulting in pyramidal tract impairment, predominantly in lower limbs. KIF1C gene has recently been identified as one of the genetic causes of HSP and associated with pure or complicated HSP. We present three patients with complicated HSP from two unrelated families, who had early onset progressive cerebellar signs and developed pyramidal tract signs during follow-up. Whole exome sequencing in these patients followed by segregation analysis identified novel truncating KIFIC mutations (c.463C> T; p.R155* and c.2478delA; p.A1a828Argfs*13). Neuroimaging findings showed cerebral and upper cervical spinal atrophy, bilateral symmetrical pyramidal tract involvement, and focal cerebral white matter lesions. Patients with KIFIC mutations may present with cerebellar signs and pyramidal findings may emerge later, therefore complicated HSP should be considered in the differential diagnosis of unidentified cases with cerebellar dysfunction. (C) 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.