A follow up study of cytomegalovirus infection in a group of Turkish renal transplant recipients using molecular assays


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Cirak M., Rota S., Maral I., Turet S., Sindel S.

MEMORIAS DO INSTITUTO OSWALDO CRUZ, vol.100, no.3, pp.263-267, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1590/s0074-02762005000300008
  • Title of Journal : MEMORIAS DO INSTITUTO OSWALDO CRUZ
  • Page Numbers: pp.263-267

Abstract

The clinical value of an in-house cytomegalovirus nested polymerase chain reaction (CMV-PCR) and a commercial molecular assay hybrid capture CMV DNA assay (HCA) was evaluated in monitoring a group of renal transplant patients for six months follow up. In this study, the sensitivity, specificity, positive predictive value, and negative predictive value of nested CMV DNA PCR assay and HCA at the beginning of the study were 70, 42.9, 46.7, 66.7, and 60, 78.6, 66.7, and 73.3% respectively. After six months, they were 80, 66.7, 80, 66.7 for CMV PCR and 73.3, 88.9, 91.7, 66.7% for HCA respectively. These results indicate that in monitoring and predicting CMV infections in renal transplant recipients, not only qualitative but also quantitative assays must be used together in order to decide the preemptive strategies.