Clinical importance of serum interleukin-18 and nitric oxide activities in breast carcinoma patients

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Gunel N., Coskun U., Sancak B., Gunel U., Hasdemir O., Bozkurt S.

CANCER, vol.95, no.3, pp.663-667, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1002/cncr.10705
  • Title of Journal : CANCER
  • Page Numbers: pp.663-667
  • Keywords: IL-18, serum, breast carcinoma, nitrate and nitrite, bone, nitric oxide, GAMMA-INDUCING FACTOR, INTERFERON-GAMMA, BONE METASTASIS, EXPRESSION, CANCER, SYNTHASE, IL-18, INHIBITION, CLONING, CELLS


BACKGROUND. Interleukin-18 (IL-18) is a novel immunoregulatory cytokine that was known previously as interferon-gamma-inducing factor. IL-18 levels can be used as a serum indicator for monitoring the clinical course of patients with hematologic malignancies and gastric carcinoma. Nitric oxide (NO) is a pleiotropic molecule that participates in the multistep processing of carcinogenesis.