Factors Associated with Cytomegalovirus Reactivation Following Allogeneic Hematopoietic Stem Cell Transplantation: Human Leukocyte Antigens Might Be Among the Risk Factors

Acar K., Aki S. Z., ÖZKURT Z. N., BOZDAYI G., Rota S., Sucak G. T.

TURKISH JOURNAL OF HEMATOLOGY, vol.31, no.3, pp.276-285, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.4274/tjh.2013.0244
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.276-285
  • Keywords: Cytomegalovirus reactivation, Human leukocyte antigens, Allogeneic stem cell transplantation, Graft-versus-host disease, Prognosis, CMV scoring index, CYTOTOXIC T-LYMPHOCYTES, VERSUS-HOST-DISEASE, ADOPTIVE IMMUNOTHERAPY, PREEMPTIVE GANCICLOVIR, PREGNANT-WOMEN, CMV INFECTION, VIRUS, DONOR, RECIPIENT, PROPHYLAXIS
  • Gazi University Affiliated: Yes

Abstract

Objective: Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (AHSCT) recipients. Current practice includes prophylactic and preemptive treatment modalities, which have risks, side effects, and costs of their own. There is no established risk scoring system that applies to all patients. We aimed to investigate the risk factors for CMV reactivation in AHSCT recipients.