ASYMMETRIC DIMETHYLARGININE (ADMA) IN ENDOCRINE DISEASES

Altinova A., Arslan M.

MARMARA MEDICAL JOURNAL, cilt.22, sa.1, ss.80-84, 2009 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.80-84
  • Anahtar Kelimeler: ADMA, NO, Endocrine diseases, Cardiovascular risk
  • Gazi Üniversitesi Adresli: Evet

Özet

Asymmetric dimethylarginine (ADMA) is the major inhibitor of nitric oxide biosynthesis in humans. Recent reports have demonstrated that elevated plasma ADMA levels are associated with endothelial dysfunction and increased atherogenesis. Elevated ADMA levels, which contribute to an increased cardiovascular risk, have been reported in several endocrine diseases. The role of ADMA in various endocrine diseases such as diabetes mellitus, obesity and thyroid dysfunction are discussed in this review.