Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility


Kocabas N., Sardas S., Cholerton S., Daly A., Elhan A., Karakaya A.

CELL BIOCHEMISTRY AND FUNCTION, vol.23, no.1, pp.73-76, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1002/cbf.1128
  • Title of Journal : CELL BIOCHEMISTRY AND FUNCTION
  • Page Numbers: pp.73-76

Abstract

Within mitochondria, manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species (ROS). An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case-control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio (OR): 0.86 (95% confidence interval (CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m(-2) (OR: 1.42 (95%CI = 1.04-1.93)). Copyright (C) 2004 John Wiley Sons, Ltd.