Hyperammonemic encephalopathy without hepatic dysfunction due to treatment with valproate: four cases and a mini review

Dincer M., Akgun A., Bodur S., Gul H., TAŞ TORUN Y., Bolu A., ...Daha Fazla

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.4, ss.448-460, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/24750573.2018.1448133
  • Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.448-460
  • Anahtar Kelimeler: Valproic acid, encephalopathy, hyperammonemia, bipolar disorder, lactulose, side effects, ACID, DISORDER, PATIENT, BRAIN, COMA
  • Gazi Üniversitesi Adresli: Hayır

Özet

Divalproex sodium/valproic acid (VPA) is an antiepileptic drug which is frequently prescribed in neurology and psychiatric clinics. Common side effects of VPA are side effects of the digestive system, weight gain, tremor, sedation, hematologic side effects and hair loss. Valproate-induced hyperammonemia is almost seen in 50% of patients treated with VPA, some of which may develop encephalopathy. Valproate-induced hyperammonemic encephalopathy (NE) is a well-known subject and there are numerous publications in the current literature. Although there is substantial evidence for this side effect in patients with neurological disorders, the data in the psychiatric area are limited. When we look at publications, it seems that VHE is seen more often because it starts earlier in psychiatric patients, but we think that it is often missed. Here, we presented five cases in which we followed up and treated with VHE diagnosis in our clinic within one year and other reports published previously in a table.