Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children - the HDF, heart and height (3H) study.


Shroff R., KARABAY BAYAZIT A., Stefanidis C. J. , Askiti V., Azukaitis K., CANPOLAT N., ...More

BMC nephrology, vol.19, no.1, pp.199, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1186/s12882-018-0998-y
  • Journal Name: BMC nephrology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.199
  • Keywords: Haemodialysis (HD), Haemodiafiltration (HDF), Children, Cardiovascular, Growth, Carotid intima media thickness (IMT), INTIMA-MEDIA THICKNESS, CHRONIC KIDNEY-DISEASE, ALL-CAUSE MORTALITY, ONLINE-HEMODIAFILTRATION, VASCULAR CALCIFICATION, PEDIATRIC-PATIENTS, DIALYSIS PATIENTS, REFERENCE VALUES, BLOOD-PRESSURE, VOLUME

Abstract

Background: Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart and height (3H) study to test the hypothesis that children on HDF have an improved cardiovascular risk profile, growth and nutritional status and quality of life, compared to those on conventional HD.