Atraumatic Osteonecrosis After Estrogen Replacement Therapy Associated with Low Protein S Level in a Patient with Turner Syndrome

Creative Commons License

Ureten K., Ozturk M. A., Bostanci A., Ceneli O., Oezbek M., HAZNEDAROĞLU İ. C.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.16, sa.5, ss.599-601, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1076029609339746
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.599-601
  • Anahtar Kelimeler: osteonecrosis, protein S deficiency, estrogen, VENOUS THROMBOSIS, DEFICIENCY, RISK, THROMBOPHILIAS
  • Gazi Üniversitesi Adresli: Evet

Özet

Atraumatic osteonecrosis has been associated with a variety of clinical conditions including corticosteroid usage, alcoholism, infections, hyperbaric events, storage disorders, marrow-infiltrating diseases, coagulation defects, and some autoimmune diseases. Osteonecrosis due to thrombophilia is an extremely rare condition with only few cases reported previously in the literature. Hormone-replacement therapies cause increased risk of venous thrombosis, probably by causing a synergistic effect with inherited clotting defects. In this article, we report a young female with Turner syndrome, who developed avascular necrosis of the femoral head during treatment with oral estrogen, which was associated with low protein S levels.