Akademik Veri Yönetim Sistemi
MEANDROS MEDICAL AND DENTAL JOURNAL, sa.4, ss.303-308, 2023 (ESCI)
Objective: Natural products with antioxidant components are believed to have a strong potential for the prevention of cancer and some degenerative diseases. Liquidambar orientalis Miller (Styrax Liquidus) has strong in vitro antioxidant activity. The purpose of this study was to evaluate the effects of Styrax Liquidus on antioxidant defense mechanisms in 7,12-dimethylbenz(a)anthracene (DMBA)-applied rat tongue tissue.Materials and Methods: Wistar rats (n=30) were randomly divided into control, DMBA, DMBA + SL, and SL groups. The control group was treated with liquid paraffin only, the DMBA group was treated with 0.5% DMBA, DMBA and Styrax Liquidus were applied to the DMBA + SL group, and only Styrax Liquidus was applied to the SL group. All applications were made to the oral mucosa. Sixteen weeks later, the tongue tissue of all animals were removed. Superoxide dismutase, catalase, glutathione peroxidase enzyme activities, and malondialdehyde and total antioxidant status levels were measured. Results: All parameters were significantly lower in the SL + DMBA group. Antioxidant enzyme activities and oxidative stress parameters were lowered in the SL + DMBA and SL groups. SL + DMBA application is believed to have an inhibitory effect on the antioxidant enzymes measured in this study; however, the decrease in malondialdehyde levels (lipid peroxidation marker) highlights the antioxidant effect of Styrax Liquidus in 7,12-dimethylbenz(a)anthracene-exposed rat tongue tissues.Conclusion: Styrax Liquidus exhibited in vivo antioxidant activity in an oral cancer model. Further research may be useful in understanding the exact mechanisms underlying this effect.