The relationship between the MEFV genotype, clinical features, and cytokine-inflammatory activities in patients with Familial Mediterranean Fever


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Colak B., Gurlek B., YEGİN Z. A., Deger S. M., Elbek S., PAŞAOĞLU H., ...More

RENAL FAILURE, vol.30, no.2, pp.187-191, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1080/08860220701810364
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.187-191
  • Keywords: Familial Mediterranean Fever, MEVF genotype, inflammation, cytokine, PROCALCITONIN, MUTATIONS, SEPSIS, AMYLOIDOSIS, ACTIVATION, INFECTION, DISEASE
  • Gazi University Affiliated: Yes

Abstract

Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by periodic attacks of fever and polyserositis. The effects of the MEFV genotype differences on clinical picture and inflammatory activity have not been well documented. The aim of this study was to investigate levels of conventional inflammation markers, procalcitonin, interleukin levels, TNF-alpha, and C5a levels in patients with FMF who had different MEFV genotypes and compare them with those of healthy subjects. The study consisted of 41 patients with FMF (F/M: 23/18), and 31 healthy subjects (F/M: 18/13). Tests were performed during the attack-free period.