The relationship between the MEFV genotype, clinical features, and cytokine-inflammatory activities in patients with Familial Mediterranean Fever

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Colak B., Gurlek B., YEGİN Z. A., Deger S. M., Elbek S., PAŞAOĞLU H., ...Daha Fazla

RENAL FAILURE, cilt.30, sa.2, ss.187-191, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/08860220701810364
  • Dergi Adı: RENAL FAILURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.187-191
  • Anahtar Kelimeler: Familial Mediterranean Fever, MEVF genotype, inflammation, cytokine, PROCALCITONIN, MUTATIONS, SEPSIS, AMYLOIDOSIS, ACTIVATION, INFECTION, DISEASE
  • Gazi Üniversitesi Adresli: Evet

Özet

Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by periodic attacks of fever and polyserositis. The effects of the MEFV genotype differences on clinical picture and inflammatory activity have not been well documented. The aim of this study was to investigate levels of conventional inflammation markers, procalcitonin, interleukin levels, TNF-alpha, and C5a levels in patients with FMF who had different MEFV genotypes and compare them with those of healthy subjects. The study consisted of 41 patients with FMF (F/M: 23/18), and 31 healthy subjects (F/M: 18/13). Tests were performed during the attack-free period.