Objective: The aim of this study was to compare and evaluate the clinical results obtained in the maxilla and mandible by taking digital impressions following application of hyaluronic acid fillers for the reconstruction of multiple papillary losses. Method and materials: Evaluation was made of a total of 200 papilla spaces in 20 patients applied with hyaluronic acid filler injection to consecutive papillae regions in both arches symmetrically. The area of the interdental space and the percentage change in the area value over time was calculated separately for each papilla space by taking digital impressions before the application of hyaluronic acid and at 3, 12, and 24 months after the application. Results: A significant improvement was determined in the area values of both arches at 3, 12, and 24 months compared to the baseline values. In the percentage change at 24 months, irrespective of whether the mandible or maxilla, the highest filling percentage of all the spaces was between the canine and lateral incisors. When the 24-month filling percentages were compared between the maxillae and mandibles, the most significant difference was between the central teeth. Conclusion: The results showed that success was obtained in both arches with hyaluronic acid filler injection applied for reconstruction of multiple papilla losses; because the filling percentages in the maxilla at 3 months and 12 months were greater than those in the mandible, it can be suggested that results can be obtained more quickly and at a higher level in the maxilla.