The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients


Yildirim Z., Yildirim F., Ucgun N. I. , Kilic N.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.128, no.2, pp.135-143, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s12011-008-8258-9
  • Title of Journal : BIOLOGICAL TRACE ELEMENT RESEARCH
  • Page Numbers: pp.135-143
  • Keywords: Senile cataract, Diabetes mellitus, Oxidative stress, Antioxidants, Trace elements, GLUTATHIONE-PEROXIDASE ACTIVITY, LIPID-PEROXIDATION, ANTIOXIDANT ENZYMES, AQUEOUS-HUMOR, PSEUDOEXFOLIATION SYNDROME, SUPEROXIDE-DISMUTASE, ZINC, COPPER, LENS, BLOOD

Abstract

The aim of the present study was to evaluate the copper (Cu), zinc (Zn), malondialdehyde (MDA), glutathione (GSH), and advanced oxidation protein products (AOPP) levels and superoxide dismutase (SOD) activities in diabetic senile cataract. Ten patients with diabetic senile cataract and ten patients with nondiabetic senile cataract (control group) were included in this study. AOPP, MDA, and GSH levels and SOD activity were measured by a spectrophotometric method. Serum, lens Cu, and Zn levels were measured by an atomic absorption spectrophotometric method. Both the lens and serum Zn and Cu levels between the two groups were not significantly different (p > 0.05). GSH, AOPP, and MDA levels and the SOD activities in the diabetic senile cataract group were significantly increased as compared to the control group (p < 0.05). Oxidative stress is one of the major factors which may lead to the early cataract formation. Oxidative events are of great importance in diabetic complications and, particularly in the lens, may have a role in the pathogenesis of cataract associated with diabetes mellitus as exhibited in this study.