Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy

Cifci S., Irak K., Bayram M., EKMEN N., Kazezoglu C., Acar Z., ...Daha Fazla

GASTROENTEROLOGIA Y HEPATOLOGIA, cilt.44, sa.2, ss.96-102, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.gastrohep.2020.08.001
  • Dergi Adı: GASTROENTEROLOGIA Y HEPATOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.96-102
  • Anahtar Kelimeler: Autotaxin, Intrahepatic cholestasis, Pregnancy, Pruritus
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy.