Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy

Cifci S., Irak K., Bayram M., EKMEN N., Kazezoglu C., Acar Z., ...More

GASTROENTEROLOGIA Y HEPATOLOGIA, vol.44, no.2, pp.96-102, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1016/j.gastrohep.2020.08.001
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.96-102
  • Keywords: Autotaxin, Intrahepatic cholestasis, Pregnancy, Pruritus
  • Gazi University Affiliated: Yes


Objective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy.