Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3

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Aktaş E., Şener E. E., Uyar Göçün F. P.

JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY, vol.12, no.3, pp.145-151, 2011 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1007/s10195-011-0154-y
  • Journal Name: JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.145-151
  • Keywords: Simvastatin, Anterior cruciate ligament transection, Knee osteoarthritis, Matrix metalloproteinase-3, TUMOR-NECROSIS-FACTOR, CARTILAGE HISTOPATHOLOGY, CYTOKINES, DEGRADATION, AGGRECAN, SERUM
  • Gazi University Affiliated: Yes

Abstract

Background We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via the inhibition of matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in a mechanically induced experimental osteoarthritis (OA) animal model.