Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19

Satış, Hasan; Özger, HASAN; Aysert Yıldız, PINAR; Hızel, Kenan; Gulbahar, ÖZLEM; Erbaş, GONCA; Aygencel, ŞAHENDER; Guzel Tunccan, ÖZLEM; Öztürk, Mehmet; Dizbay, MURAT; Tufan, ABDURRAHMAN

doi:10.1016/j.cyto.2020.155302

Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19

Satış H., Özger H. S., Aysert Yıldız P., Hızel K., Gulbahar Ö., Erbaş G., ...More

CYTOKINE, vol.137, 2021 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 137
Publication Date: 2021
Doi Number: 10.1016/j.cyto.2020.155302
Journal Name: CYTOKINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: COVID-19, Interleukin-18, Cytokine, Prognosis, Intensive care unit, IL-18
Gazi University Affiliated: Yes

Abstract

Background: The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19.